Anchored cAMP signaling: onward and upward - a short history of compartmentalized cAMP signal transduction.
نویسندگان
چکیده
Intracellular signal transduction pathways require a high degree of spatial and temporal resolution in order to deliver the appropriate outputs. Specific signaling mediated by the ubiquitous second messenger cAMP and its effector, the cAMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A-kinase anchoring proteins (AKAPs). This review discusses the history and future of anchored cAMP signaling pathways.
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ورودعنوان ژورنال:
- European journal of cell biology
دوره 85 7 شماره
صفحات -
تاریخ انتشار 2006